How much bromelain for inflammation

If you buy through links on this page, we may earn a small commission. Bromelain is an enzyme mixture present in the pineapple. People tend to use bromelain as a supplement for various health benefits, including relieving sinus problems, reducing inflammation, and improving digestion.

There is varied scientific evidence surrounding the effectiveness of using bromelain for these purposes. This article will look at the reported benefits, as well as the potential risks, of using bromelain.

Bromelain is an enzyme mixture that people can extract from the stem or fruit of the pineapple plant Ananas comosus. Healers have used these enzymes for hundreds of years in many ways. Now, retailers tend to sell bromelain either as a health supplement or skin cream. Bromelain is a mixture of enzymes that have active effects in the body. The active ingredients in bromelain include proteinases and proteases, which are enzymes that break down proteins in the body.

People use bromelain as a natural remedy for many health issues. There is little quality scientific research to support many of its use, however. Bromelain may be helpful as a supportive therapy to reduce the symptoms of sinusitis and related conditions that affect breathing and the nasal passages. A review of studies suggests that bromelain may reduce the duration of sinusitis symptoms in children, improve breathing, and reduce nasal inflammation.

A systematic review reports that bromelain, when a person uses it alongside standard medications, can help relieve inflammation in the sinuses. This study provides high-quality evidence, as it looked at 10 randomized control trials. A review of clinical studies found that bromelain is a useful treatment for osteoarthritis, possibly due to its anti-inflammatory effects.

The researchers say that further research is needed into the effectiveness and suitable dosages. However, this is an older study, and the National Institutes of Health NIH say that the research to date is mixed about whether bromelain, alone or with other medications, is effective in treating osteoarthritis. Along with reducing nasal inflammation in sinusitis, bromelain may also reduce inflammation elsewhere in the body. According to a review of studies , research in cell and animal models has suggested that bromelain can reduce certain compounds associated with cancer inflammation and tumor growth.

Bromelain also may help stimulate a healthy immune system to release inflammation-fighting immune system compounds. The review also suggests that bromelain can reduce transforming growth factor beta, which is a compound associated with inflammation in rheumatoid arthritis and osteomyelofibrosis. However, scientists had conducted many of these studies on mice or in a cell-based laboratory setting, so researchers do not currently know the effects that bromelain has in humans.

A randomized, double-blind study versus diclofenac. Clin Drug Invest. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs.

Clin Exp Rheumatol. Masson M. Bromelain in blunt injuries of the locomotor system. A study of observed applications in general practice. Fortschr Med. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn. Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines. Int J Oncol. Bromelain prevents secretion cased by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro.

Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro. Clin Immunol. Plast Reconstr Surg. Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma. Cancer Invest. Safety and efficacy of a proteolytic enzyme for enzymatic burn debridement: a preliminary report.

Sanders HJ. Therapy of chlamydia infections with tetracyclines. Int J Exp Clin Chemother. Oral bromelain attenuates inflammation in an Ovalbumin-induced Murine Model of Asthma.

Evid Based Complement Alternat Med. Naturopathic treatment of rotator cuff tendinitis among Canadian postal workers: a randomized controlled trial. Arthritis Rheum. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple Ananas comosus and its clinical application. An update. J Ethnopharmacol. Attenuation of contraction-induced skeletal muscle injury by bromelain. Med Sci Sports Exerc. Bromelain ameliorates the wound microenvironment and improves healing of firearm wounds.

J Surg Res. Bromelain Ananas comosus; Bromelainum. Dietary Sources Bromelain is found in the common pineapple plant, but not in high enough doses to act as medicine. Available Forms Bromelain is available in tablet or capsule form for use by mouth. Adults The German Commission E recommends 80 to mg, 2 to 3 times per day. Precautions Supplements may have side effects or interact with medications.

Side effects from bromelain are generally mild and include: Nausea and vomiting Diarrhea Excessive menstrual bleeding People who are allergic to pineapples, Latex, wheat, celery, papain, carrot, fennel, cypress pollen, or grass pollen may also be allergic to bromelain.

Bromelain may make sedative drugs stronger, including:. Bromelain is a natural substance derived from pineapples. It has been studied extensively and may have significant, positive effects on multiple health conditions, including burns, osteoarthritis, and cancer.

Discuss your use of bromelain with your doctor, particularly if you take prescription medications. Pineapple juice contains a variety of vitamins, minerals, and beneficial plant compounds that may protect you from disease.

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